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alcohol is a trickster ponypuristiguess No.29746[Reply]

File: 1794405967537.jpg (65.68 KB, 474x661, trickster.jpg)

new research on how alcohol affects the brain. it all suddenly makes sense now

https://neurosciencenews.com/alcohol-microglia-neuroscience-31311/

tl;dr: alcohol doesn't just modify various receptor pathways. much of its effect is from tricking the brain into retracting its extracellular matrix. when you drink, you are not merely taking a substance that modifies receptors and exerts toxic effects on your body -- you are also consenting for the substance to trick your own biology into retracting its caretaking of your brain

it is uncertain if this is different from most other drugs, but i assume yes it is different

this also explains why spiritual people say alcohol forces the lowering of your auric shield, but it never explained why. this new research proves, perhaps conclusively, that alcohol, if imbibed, may be a form of biological dark magic

fascinating

nonutnovember theponyknownasponypurist No.29411[Reply]

File: 1793518422638.png (455.99 KB, 767x718, nnn-time.png)

it's that time again
15 posts and 12 image replies omitted. [View]

ponypuristiguess No.29693

File: 1794266673128.webp (65.96 KB, 1080x809, nnnmeme.webp)

>>29692

⛵ No.29705

File: 1794293606995.jpg (70.84 KB, 552x363, 9BF3E1FB-F383-4389-8903-B8A584…)

>>29693 what is this "horny" of which you speak?

ponypuristiguess No.29745

File: 1794405309555.jpg (747.58 KB, 1280x720, pond2.jpg)

>>29705
it can get that way a little sometimes .... spent yesterday cleaning up my apartment

days slowing down

Walter Koenig sciamano240 No.29195[Reply]

File: 1793065091184.webp (32.06 KB, 632x437, IMG_2295.webp)

RIP
https://universeodon.com/@georgetakei/117508141846800669
3 posts and 2 image replies omitted. [View]

Moony No.29220

File: 1793128777115.jpg (45.93 KB, 736x1016, b1d113d50193954bde0294f96514df…)

>>29219
Celebrity deaths are a reminder of that life is short. Many on the internet waste their time fighting wars they don't want to fight but they feel they need to fight, wasting valuable time on this earth.

Who?!kAyKD8aAEI No.29221

File: 1793129583609.png (358.31 KB, 1318x1100, LunaThumbsUp.png)

>>29220
100% in agreement there.

Anonymous No.29744

File: 1794392461467.jpg (77.1 KB, 1196x720, @rave.jpg)

Who is next?

RIP Anonymous No.26725[Reply]

File: 1787914198838.jpg (9.51 KB, 160x213, 20260830.jpg)

Dolly Parton
[YouTube: Remembering an American Icon: Dolly Parton (1946-2026)]
5 posts and 2 image replies omitted. [View]

Anonymous No.28895

Working 9 to 5....

Anonymous No.29196

I don’t wanna believe

Anonymous No.29743

*sigh*

=^-^= Nonny No.29742[Reply]

File: 1794387283803.png (308.26 KB, 560x551, 1000003106.png)

I thought no one would think about me
But it's not surprising that you thought about me
I thought you'd feel like an ocean, all reactive
And lucid in emotion, why'd you think about me?

Muscle Moonday Anonymous No.27256[Reply]

File: 1788764855213.jpg (203.86 KB, 850x1095, @gouki.jpg)

Remember to exercise at least 30 min a day.
14 posts and 11 image replies omitted. [View]

Anonymous No.29169

File: 1793006450527.jpg (732.16 KB, 952x1248, 20261102.jpg)

LIFT THEM WEIGHTS

Chain No.29200

File: 1793066648976.jpg (130.77 KB, 850x1151, 24217.jpg)

I remember a decade or two ago when I thought that a billion weights was a lot.

Anonymous No.29740

File: 1794377668178.jpg (146.5 KB, 1200x675, @cho.jpg)

Lift them. Lift them high!

Steam hardware from Valve Anonymous No.19662[Reply]

File: 1763540118753.webp (42.12 KB, 601x680, web.webp)

It's happening!
[YouTube: Steam Hardware Announcement]
16 posts and 11 image replies omitted. [View]

Anonymous No.28602

File: 1791794970962.jpg (153.24 KB, 819x1200, IMG_2231.jpeg)

Giving Fightcade a go….

Anonymous No.29210

File: 1793101842422.jpg (156.14 KB, 1157x1200, 20261029.jpg)

I need more RAM

Anonymous No.29739

File: 1794376073381.jpg (83.76 KB, 1199x709, @rave.jpg)

Oh my...
The prices of electronics is sooooo high

Anonymous No.29717[Reply]

File: 1794341960123.jpg (61.96 KB, 736x605, 1000003772.jpg)

Can we permaban nonny already? Pls/TY
1 post omitted. [View]

Nonny No.29724

File: 1794365541639.gif (1.65 MB, 471x498, drinking water.gif)

I just made Squid soup ramen.

Fucking so good!

⛵ No.29729

File: 1794370300137.gif (3.09 MB, 480x360, cmc_snorkeling.gif)

>>29724

Nonny No.29738

File: 1794375849990.png (308.26 KB, 560x551, Nonny.png)

>>29729
I thought no one would think about me
But it's not surprising that you thought about me
I thought you'd feel like an ocean, all reactive
And lucid in emotion, why'd you think about me?

Maroon Auburn!QEUQfdPtTM No.25192[Reply]

File: 1785440749968.jpg (166.68 KB, 901x630, lol.jpg)

Anyone got a spare $9,000?
13 posts and 8 image replies omitted. [View]

Anonymous No.28591

File: 1791783473909.jpg (898.35 KB, 2484x4096, IMG_2225.jpeg)

>>28165
Nice tattoo on the beach

Anonymous No.29209

File: 1793101662080.jpg (184.46 KB, 850x1176, 20261029.jpg)

Give me

Anonymous No.29737

File: 1794375673288.webp (134.29 KB, 819x1023, webp.webp)

All your graphics cards are belong to us.

https://www.chessgames.com/puzzle.html Anonymous No.20416[Reply][+50]

File: 1765802473263.gif (4.46 KB, 268x268, 00.gif)

Black to play
A Budo vs Taimanov
https://www.chessgames.com/perl/chessgame?gid=1137688&m=40.5
117 posts and 103 image replies omitted. [View]

Anonymous No.29677

File: 1794211566090.gif (4.66 KB, 268x268, 01.gif)

White to play
L Comas Fabrego vs L Rogule
https://www.chessgames.com/perl/chessgame?gid=1371503&m=28

Anonymous No.29703

File: 1794289777110.gif (4.34 KB, 268x268, 01.gif)

White to play
D Feletar vs Delchev
https://www.chessgames.com/perl/chessgame?gid=1406227&m=35

⛵ No.29722

File: 1794350809358.png (1.44 MB, 1230x845, 500368__safe_princess+luna_idw…)

>>24976 nope

>>25001
White: bishop g5
Black: queen x bishop
White, knight f7, check
Black: king x knight
White: knight x queen, check

actual game: same

>>25112 mate in 2
White: queen x h7, check
Black: king x queen
White: pawn x knight, checkmate
Post too long. Click here to view the full text.

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